The CCK-8 assay and Annexin V-FITC/propidium iodide staining assay demonstrated that knockdown of YTHDC1 decreased the sensitivity of renal cancer cells to sunitinib (Fig. 6C and D, Supplementary Fig. 3 A), but overexpression of YTHDC1 led to sunitinib resistance in renal cancer cells (Fig. 6E F, Supplementary Fig. 3B). The gene discussed is ANXA5; the disease is renal carcinoma.