MT-ND5 and neoplasm: In addition, mitochondrial mutations common to different subclonal tumor cells in different tumor regions are basically homoplasmic mutations (MT-ND5: 13368 G>T in patient #1, MT-CO1: 7352 T>C in patient #5, MT-ND1: 4049 G>A in patient #7, MT-ND5: 13526 C>A in patient #8), while most of the mutations shared by some subclonal cells are heteroplasmic mutations (Fig. 5C, F and Additional file 2: Fig. S7, S9A).