In details, both lymph node metastatic tumor cells and the primary tumor OLFM4+SOX9+ C-type cells highly expressed intestinal stem cell markers (SOX9 and LGR5), TP53RK (TP53 regulating kinase), and TPRKB (TP53RK binding protein) (Fig. 7C and Additional file 2: Fig. S10C). This evidence concerns the gene LGR5 and neoplasm.