In patient #3, a small number of cells without clear CNVs (D-type) from tumor tissues clustered with adjacent normal cells based on transcriptome data, and these cells did not have mutations in MT-RNR2 (chrM:3004), which was shared by tumor cells with clear CNVs (Additional file 2: Fig. S6B-D). This evidence concerns the gene MT-RNR2 and neoplasm.