Interestingly, in patient #2, majority of the tumor epithelial cells in the primary tumor had a heteroplasmic mutation in MT-ND3(chrM:10192), but at liver metastasis (LM) region, almost all cells had homoplasmic mutations at MT-ND3(chrM:10192) (Additional file 2: Fig. S8A-B). This evidence concerns the gene MT-ND3 and neoplasm.