High expression of NLRP3, caspase-1, IL-1β, and IL-18 and over-activated NLRP3 inflammasome were found in skin biopsy specimen from SSc patients and showed a positive correlation with modified Rodnan skin thickness score (mRSS), a measure of skin involvement, in which higher scores represent severe skin fibrosis [59]. The gene discussed is CASP1; the disease is systemic sclerosis.