The analysis of the levels of immunoreactivity (IR) for IBA1, a homeostatic microglial protein essential for microglial migration and phagocytosis, showed an increase in the CA (p = 0.043), with a similar trend in the DG (p = 0.124) and LEC (p = 0.05) of AD rats compared to controls (Fig. 7A, B). This evidence concerns the gene AIF1 and Alzheimer disease.