Dong et al. proved that METTL14 depletion in CRC-associated macrophages can induce epstein-Barr virus induced 3 (EBI3) upregulation in an m6A dependent manner mediated by YTHDF2, contributing to CD8+ T cells dysfunction, thereafter accelerating malignant progression of CRC, which was verified by mouse models and clinical samples [109]. The gene discussed is YTHDF2; the disease is colorectal carcinoma.