Recently, Tian et al. showed that the variant rs8100241[A] of tumor suppressor ankyrin repeat and LEM domain-containing protein 1 (Ankle1) could be more efficiently catalyzed by METTL14 and recognized by YTHDF1, thus upregulating m6A methylation level and protein expression of ANKLE1, which correlates with a reduced risk of CRC by suppressing tumor malignant proliferation and maintaining the genomic stability [117]. The gene discussed is ANKLE1; the disease is neoplasm.