Taken together, our results are consistent with earlier studies with photosensitizers (hypericin [33], photosens and photodithazine [36], 5-ALA [48], Rose Bengal [49], glycoconjugated chlorin [50], pz I and pz III [37]) in which the data showed that PDT induces ICD, mainly through DAMPs signals from dying cells which could trigger anti-tumor immunity. Here, PROZ is linked to neoplasm.