Similarly, deletion of CSMD1 (CUB and Sushi multiple domains 1), a tumor suppressor gene at 8p23, which has been associated with poor prognosis in many solid tumors, including breast, gastric, squamous, head and neck, and hepatocellular carcinomas [19, 26] emerged as recurrent CNA in T-ALL, occurring in 2% of cth− cases. Here, CSMD1 is linked to acute lymphoblastic leukemia.