Cth+ cases were characterized by a significant over-expression of MYCN, GATA2 and CD33, as observed in immature T-ALL, and down-regulation of ATM and RGCC, both involved in DNA Double-Strand Break Repair and Apoptosis; no other DNA repair/mismatch or genomic stability genes belonged to the DEGs. This evidence concerns the gene RGCC and acute lymphoblastic leukemia.