CRELD2 is an ER-stress inducible gene14 expressed in the developing skeleton and has been implicated in the pathogenesis of skeletal dysplasias such as multiple epiphyseal dysplasia15 and metaphyseal chondrodysplasia type Schmid16, which are characterised by prolonged ER stress due to the retention and accumulation of mutant protein within the ER. The gene discussed is CRELD2; the disease is skeletal dysplasia.