Consistently, RPLP0 silencing significantly inhibited radiation-induced DNA-PK autophosphorylation at T2609 in tumor cells (Fig. 5F), which photocopied RPLP0 silencing (Fig. 5E), indicating that the NONO/RPLP0 complex may promote NHEJ by enhancing DNA-PK autophosphorylation at T2609. The gene discussed is PRKDC; the disease is neoplasm.