We derived fibroblasts from skin biopsies of two patients with genotype- and phenotype-confirmed RP who harbored mutations in PRPF31, either duplication in exon 8 (c.709_734dup) referred as Cys247X or deletion in exon 4 (c.269_273del) referred to as Tyr90CysfsX21, both causing premature termination of protein translation10. The gene discussed is PRPF31; the disease is retinitis pigmentosa 1.