Notably, impaired splicing events are observed in different genes involved in RNA processing pathways including the splicing program itself both in iRPE cells and retinal organoids, suggesting that exacerbation of splicing deficiencies contributes to the defective phenotype observed in retinal cells and thus probably in PRPF31-related RP patients. The gene discussed is PRPF31; the disease is retinitis pigmentosa 1.