Of note, we found that at MH stage, loss of FOXA2 led to a significant increase in the expression of mRNA levels of genes associated with hepatic fibrosis and HSC activation, such as PDGF [39], MMP2 [38], TGFβ2, TGFβ3, TGFβR2 [40, 41], and DLK1 [42] among others. This evidence concerns the gene TGFBR2 and Hepatic fibrosis.