PDGFRA and diffuse midline glioma: While H3F3A/B gene sequencing was not available for all cases, some pediatric tumors strongly associated with OPC-like differentiation and PDGFRA expression (e.g., BT749, BT786) had midline and/or caudal anatomic locations (bifrontal, posterior fossa)41, suggesting that these samples may represent diffuse midline gliomas, the pediatric HGG subtype with the worst overall prognosis18.