HIF1A and neoplasm: In keeping with the single-cell association between HIF1a and CD73 (Fig. S10i), CD73 and hypoxic myeloid populations (Fig. 2J, K), and the regional association between CD73 and hypoxia (Fig. 7F–I), spatial statistics showed a strongly significant correlation between tumor CD73 and HIF1a protein expression (in any cell population) (p = 5.56e−56) (Fig. 8H).