Analysis of adenosine receptors showed that expression of ADORA2A/A2AR and ADORA2B/A2BR in glioblastoma and diffuse glioma were moderate compared to that of other cancers, while ADORA1/A1R and ADORA3/A3R were expressed at significantly higher levels in glioblastoma compared to all other tumor types (Fig. S5b–d and Supplementary Data 4). This evidence concerns the gene ADORA2B and neoplasm.