SOX2 and neoplasm: Examination of lineage-specific marker expression revealed four principal clusters corresponding to tumor and glia (using the SOX2, OLIG2, GFAP markers), lymphoid cells (CD45, CD3, CD8, and CD4), myeloid cells (CD45, PU.1, CD163, CD68, and CD11b), and endothelial cells (CD31) (Fig. 7B).