In scRNA-seq data from 28 adult and pediatric HGG samples41, analysis of lineage-specific markers for microglia and peripheral macrophages showed that most myeloid cells in glioblastoma (70–80%) exhibit a microglial expression signature (e.g., P2RY12, TMEM119, SLC2A5, and CX3CR1 genes) rather than a peripheral macrophage signature (e.g., CCR2, CLEC12A, F10; 20–30% of cells) (Fig. 2A, B). This evidence concerns the gene P2RY12 and glioblastoma.