Analysis of all common sequence (447 genes) and chromosomal (genome-wide) variants was notable for a significant positive correlation between CD73 protein expression (by IHC) and EGFR amplification (p = 0.029) (Fig. 5B), consistent with the link we identified between CD73 expression and the EGFR-associated AC-like state in scRNA-seq data from adult glioblastoma as well as reports of EGFR-mutated NSCLC expressing higher levels of CD73 compared with EGFR wild-type tumors59,60. This evidence concerns the gene EGFR and non-small cell lung carcinoma.