When this work was in progress, another group recently reported that DDX39B facilitated the proliferation and metastasis of CRC through enhancement of CDK6/CCND1 and FUT3 pre-mRNA splicing, respectively.46,47 These studies focused on the canonical RNA helicase DDX39B, while our work uncovered an important connection between DDX39B and glucose metabolism alterations and expanded the nonhelicase function of DDX39B via protein–protein interactions. The gene discussed is CDK6; the disease is colorectal carcinoma.