Unlike tumors such as estrogen receptor-positive breast cancer which takes years or decades to develop into metastatic entities, systemic dissemination and colonization to regional lymph nodes or distant tissues can rapidly occur during progression from colorectal adenomas to locally invasive carcinomas.48,49 Given the roles of DDX39B in the invasion and metastasis of CRC, we propose that the evaluation of DDX39B expression may provide a potential predictor of metastasis risk for individual CRC patients. Here, ESR1 is linked to invasive carcinoma.