MPP-L and CMP-L are also enriched in secondary AML (s-AML) mutations [37] in normal karyotype (n = 200, Supplemental Fig. 3A, B): ASXL1 (MPP-L RR:6.1; p = 0.0006), SRSF2 (MPP-L RR:5.0; p = 0.0021), EZH2 (MPP-L RR:7.7; p = 0.024), ZRSR2 (MPP-L RR:5.8; p = 0.046), STAG2 (MPP-L RR:2.9; p = 0.092), and SF3B1 (CMP-L RR:3.3; p = 0.050), BCOR (CMP-L RR:2.7; p = 0.089). Here, EZH2 is linked to acute myeloid leukemia.