When H929-KD or U266-KD target cells were co-cultured with patient T cells (n = 5) (E:T = 1:1), co-treatments with LY-411575 still significantly enhanced PL33-induced MM cell killing as early as 4 h (P < 0.03) and continued to increase at 1 day (P < 0.05), reaching maximal lysis associated with increased % CD107a- patient T cells (Supplementary Fig. S2D). The gene discussed is LAMP1; the disease is Miyoshi myopathy.