CAMK2G and Hyperglycemia: Hyperglycemia has been shown to enhance O-linked-N-acetylglucosaminylation (O-GlcNAcylation) of CaMKII, and studies from the Bers group (18, 23, 26) suggest that this modification enhances CaMKII activity and downstream consequences such as spontaneous sarcoplasmic reticulum (SR) Ca2+ leak.