Acquired cardiac diseases associated with ventricular arrhythmias such as cardiac glycoside toxicity (152), alcoholic cardiomyopathy (153), heart failure, and myocardial hypertrophy appear to share a final common pathway: CaMKII-dependent RyR2 hyperphosphorylation with increased SR Ca2+ release (154–156), reduction of myofilament activator Ca2+, and proarrhythmia. The gene discussed is CAMK2G; the disease is cardiac hypertrophy.