AAV9 was able to selectively infect cardiac tissue, sustain robust expression, and ameliorate arrhythmogenesis, RyR2 Ca2+ leak, and CaMKII activity in CPVT mouse models and human induced pluripotent stem cell–derived cardiomyocytes (145). Here, RYR2 is linked to catecholaminergic polymorphic ventricular tachycardia.