CaMKII has been implicated in the progression of pathological myocardial hypertrophy and dilated cardiomyopathy (114), maladaptive phosphorylation of Ca2+ handling proteins that contributes to arrhythmia, loss of myofilament contraction activating Ca2+ (115, 116), adverse metabolic reprogramming (33), activation of inflammation (38, 43, 46, 117), augmenting myocardial cell death (118, 119), and disrupting DNA repair (29). The gene discussed is CAMK2G; the disease is cardiac hypertrophy.