In fact, on one side, mutations in KCNQ2,KCNQ3, and KCNQ5 genes encoding for Kv7.2, Kv7.3, and Kv7.5 subunits,respectively, are associated with a spectrum of seizure disordersranging from self-limited familial neonatal epilepsy to severe epilepticand developmental encephalopathies.5 Onthe other, pharmacological activation of Kv7 channels appears as arational approach to treat epilepsy as well as other neuropsychiatricdisorders in which neuronal hyperexcitability plays a critical role,such as neuropathic pain, ischemic stroke, and amyotrophic lateralsclerosis. Here, KCNQ5 is linked to ischemic stroke.