For Meta-analysis of HIF1A 1772 C/T and 1790 G/A polymorphisms, the types of diseases included (after excluding all types of cancer) were grouped as cardiovascular diseases (CVDs), type 2 diabetes (T2D), autoimmune diseases, inflammatory diseases, chronic obstructive pulmonary disease (COPD), preeclampsia, skin disease, diabetic complications, and other (age-related macular degeneration (AMD), Hemodialysis, lumbar disc degeneration (LDD), high altitude polycythemia (HAPC), metabolic syndrome, pressure injury). This evidence concerns the gene HIF1A and Lhermitte-Duclos disease.