IL10 and intestinal obstruction: In addition to impairing immune T cell function through tryptophan starvation, high levels of KA produced by DCs and tumors under inflammatory conditions caused by bowel obstruction can activate IL-10 in DCs and NK cells though AhR activating [36] and IL6 transcription in cancer cells and macrophages [37] in the absence of Trp, which causes immunosuppression and immune tolerance.