As shown in Figure 8, E–H, the murine tumors showed that TDO2+ myofibroblasts were also mainly located in the distal area of the tumor nests and that CD4+ and CD8+ T cells were mainly located around TDO2+ myofibroblasts, consistent with the results observed in human OSCC tissues (Figure 5, B–G). Here, TDO2 is linked to neoplasm.