To this end, the infected cells were subjected to Western blot analysis, and the results revealed that infection led to the release of the N-terminal domain of GSDME (GSDME-N), whereas no cleavage of GSDMD was observed (Figure 1C), implying that ZIKV infection may induce pyroptosis through GSDME. The gene discussed is GSDMD; the disease is Zika virus infectious disease.