IFNA1 and Zika virus infectious disease: However, considering the fact that utilizing immunocompromised mice may prevent us from objectively assessing the potential impact of host innate immune responses on the pathogenesis of ZIKV and that the IFN signaling was found to play a vital role in mediating fetal demise after ZIKV infection by causing abnormal placental development (Yockey et al., 2018), the pregnant immunocompetent mouse model was employed in this study.