Specifically, LHb hyperactivity/dysfunction is a common finding associated with anhedonia and social withdrawal which reflect some of the core features of reward and motivational deficits seen in depressed humans.14,20-22 Not surprisingly, LHb represents a critical brain region that can be targeted for treatment of reward dysregulation in mood disorders.18,23–26 However, whether LHb dysfunction plays a role in mTBI-induced psychopathology remains unexplored. This evidence concerns the gene LHB and mood disorder.