LHB and concussion: Interestingly, behavioral avoidance from social interaction can be triggered after stimulation of LHb activity by PFC inputs in rats.44 Moreover, optogenetic stimulation of mPFC-projecting LHb neurons during the forced swim test in rats decreases the frequency of kicks (as a measure of active escape behavior), which corresponds to increases in immobility (passive coping behavior).43 This may suggest that rather than direct mPFC projections to LHb, the indirect mPFC projections through other LHb-projecting areas are involved in behavioral deficits following mTBI.