LHB and concussion: Given the complexity of LHb upstream and downstream circuits in mediating different aspects of motivated and affective behaviors, it would be worthwhile to employ an intersectional DREADD-based approach combined with optogenetics and electrophysiology to investigate causal roles of distinct intrinsic and extrinsic inputs to LHb and related LHb subpopulations and synaptic adaptations in mTBI-induced social and motivational deficits.