LHb projects to the substantia nigra, VTA, rostromedial tegmental area (RMTg), dorsal raphe nucleus (DRN), locus coeruleus, and periaqueductal gray.8,13 Promotion of LHb hyperactivity with excitatory synaptic inputs or dampening of inhibitory inputs mediates behavioral aversion, lack of motivation, anxiety and depressive phenotypes. Here, LHB is linked to Anxiety.