AFP and hepatocellular carcinoma: However, higher HSP90α was associated with older age ≥ 65 (p = 0.001), increased AFP ≥ 400 ng/mL (p < 0.001), male gender (p < 0.001), multiple HCC tumors (p < 0.001), more aggressive Child grade (p < 0.001) and ALBI score (p < 0.001), larger tumor diameter (p < 0.001), and more aggressive BCLC staging (p < 0.001) (Fig. 4).