By utilizing univariate and multivariate analyses, we confirmed the HSP90α ≥ 143.5 ng/mL (p < 0.001), AFP ≥ 400 ng/mL (p = 0.043), child B plus C (p = 0.013), ALP ≥ 125 U/L (p < 0.001), tumor number ≥ 2 (p = 0.010), no any anti-tumor tumors (p < 0.001), and more advanced BCLC staging (p = 0.006), and these were independent risk prognostic factors for OS (Table 2). This evidence concerns the gene AFP and neoplasm.