Hara-Chikuma and Verkman found that glycerol permeability via AQP3 is required for epidermal cell proliferation and tumorigenesis, as cellular glycerol is a key determinant of cellular ATP energy [15]; also, AQP3/PLD2 signaling module may be involved in the process of converting glycerol to phosphatidylglycerol in squamous cell carcinoma and basal cell carcinoma [16]. This evidence concerns the gene AQP3 and squamous cell carcinoma.