ORMDL3 and hepatocellular carcinoma: In summary, in the presence of sorafenib, silencing ORMDL3 increased mitochondrial superoxide level and reduced mitochondrial energy of HCC cells, indicating that silencing ORMDL3 caused mitochondrial dysfunction in HCC cells, which may be an important reason for increasing the apoptosis of HCC cells induced by sorafenib, which also needs further verification and exploration.