The results of Western Blot showed that the expression of Cleaved Caspase 9, Cleaved Caspase 3, and Cleaved PARP in ORMDL3-silenced HCC cells was increased, the expression of apoptotic protein Bax was increased, and the expression of anti-apoptotic protein Bcl-2 was decreased (Fig. 4E, F). This evidence concerns the gene CASP9 and hepatocellular carcinoma.