Transwell invasion assay (Fig. 2C and G) and the expression alterations of cancer metastasis-associated proteins (MMP2/9, TIMP1/2) (Fig. 2D and H) showed an accelerative effect of RP11-79H23.3 siRNA on the metastasis capability of NSCLC cells. The gene discussed is TIMP1; the disease is non-small cell lung carcinoma.