The peripheral role of phoenixin in such conditions comprises not only the systemic effect on ameliorating obesity, but also its highlighted local gonadal improvement of mitochondrial dynamics and upregulation of GnRHR mRNA abundanc which are suggested to improve ovarian cellular resistance to obesity-induced inflammatory, oxidative, and apoptotic stress leading to better cell survival and steroidogenesis. This evidence concerns the gene GNRHR and obesity due to melanocortin 4 receptor deficiency.