However, further research is required to fully understand its safety limits and toxicity, verify its effect on the ovarian protein content of DRP-1, MFN-2, and GnRHR rather than their mRNA abundance, and study its effect on ovarian gene expression of gonadotropin receptors in obese females and its effect in other cases of fertility impairment such as polycystic ovary syndrome. Here, GNRHR is linked to polycystic ovary syndrome.