SARS-CoV-2–specific tissue-resident T cells have been observed in human lymph nodes and multiple organs (particularly in the lungs) in SARS-CoV-2–infected individuals (Grau-Expósito et al., 2021; Poon et al., 2021), and an analysis of the TCR repertoire of T cells purified from the upper airway of four SARS-CoV-2–infected individuals showed a persistence of Spike-specific CD8+ T cells in the nasal cavity ≤2 mo after infection (Roukens et al., 2022). The gene discussed is CD8A; the disease is infection.