On the one hand, the GSDMD-N domain was reported to have detrimental roles in metabolic liver diseases, such as nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) as removal of Gsdmd could protect mice from these kinds of liver diseases (8, 9). The gene discussed is GSDMD; the disease is metabolic dysfunction-associated steatohepatitis.