Interestingly, although the mechanisms underlying this neuronal hyperplasia are not well understood, it is clear that mutations in the endogenous Alk locus collaborate with the MYCN oncogene to drive highly penetrant and aggressive neuroblastoma in mice (Borenäs et al., 2021; Cazes et al., 2014; Ono et al., 2019). The gene discussed is ALK; the disease is neuroblastoma.