Expression of various virulence determinants, such as adhesins, germ tube formation, phenotypic switching, and hydrolytic enzymes such as lipases, esterases, hemolysins, phospholipases, and proteinases (secreted aspartyl proteases [Saps]), varies depending on different factors, including the stage and site of infection, the species involved, geographical origin, type of infection, and host response. Here, SKAP2 is linked to infection.