Late-onset neurodegenerative disease observed in some patients with GD1 (Bultron et al., 2010) appeared to be recapitulated in Gbafl/flCx3cr1Cre/+ mice having slow progressive neuroinflammation with accumulation of GluCer lipids in the brain, elevated serum Nf-L, and DAM gene signatures. Here, NEFL is linked to neurodegenerative disease.