A similar phenomenon has been reported both in Dravet syndrome patients carrying SCN1A pathogenic variants (Perucca and Perucca, 2019) and in mice modeling Scn1a haploinsufficiency (Scn1a+/-; Hawkins et al., 2017). The gene discussed is SCN1A; the disease is encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.