Here, we show that transient blockade of pyruvate influx into mitochondria has opposite effects in PCa cell lines and non-carcinoma prostate cell lines, and causes a glycolytic potential (GP) phenotype in the former, in a manner potentially regulated by the VDAC1-MPC-mitochondrial homeostasis-glycolysis pathway. The gene discussed is VDAC1; the disease is posterior cortical atrophy.