Changes in the vasculature and underlying regulatory pathways, as mediated by vascular endothelial growth factor (VEGF) have been increasingly observed in human and experimental models of epilepsy (Croll et al., 2004; Morin-Brureau et al., 2011; Ndode-Ekane et al., 2010; Sun et al., 2016; Vezzani, 2005; Zhai et al., 2016; Tang et al., 2017). This evidence concerns the gene VEGFA and epilepsy.