For more than two decades, B16-F1 melanoma cells have been regarded as a well-established model system of actin-based protrusion, migrating by employing broad and flat lamellipodia in regular growth medium when seeded on laminin (Ballestrem et al., 1998; Rottner et al., 1999a; Svitkina et al., 2003). This evidence concerns the gene LAMB2 and melanoma.