Likewise, loss of WRC function in tumor cells migrating in 3D appears to promote N-WASP-dependent invasion (Tang et al., 2013), indicating complex, perhaps condition- and context-dependent interrelationships between the functions of the WRC and WASP and/or N-WASP in regulating Arp2/3-dependent actin remodeling at the cell periphery. The gene discussed is WASL; the disease is neoplasm.