Participants aged 16 years and older admitted to the emergency department with right iliac fossae pain, raised WCC/CRP, fluent in English (and negative β-HCG in females) were screened for inclusion.Participants without exclusion criteria would then proceed to radiological investigation with abdominal ultrasound with/without magnetic resonance imaging performed in those under 45 years; CT in participants above 45 years of age was performed.Participants were randomized if acute uncomplicated appendicitis was evidenced from radiological investigation. The gene discussed is CRP; the disease is appendicitis.