In this regard, clinical evidence also supports the involvement of these newly described pathways in the context of ischemic stroke, since neuronal antigens, including microtubule‐associated protein‐2 (MAP‐2) and N‐methyl D‐aspartate (NMDA) receptor subunit NR‐2A have been also observed in the draining lymph nodes of patients within the subacute phase after ischemic stroke (mean collection time: 76 h ± 34 h) (Planas et al, 2012). This evidence concerns the gene GRIN2A and ischemic stroke.