It attenuates ischemic stroke‐induced neuronal injury by restricting oxidative stress through the glycogen synthase kinase‐3β/nuclear factor‐erythroid 2‐related factor 2 (GSK3β/Nrf‐2) and inositol‐requiring enzyme 1α/TNF‐receptor−associated factor 2/C‐Jun N‐terminal kinase (IRE1α/TRAF2/JNK) pathways (Xu et al., 2021). This evidence concerns the gene ERN1 and ischemic stroke.