TNF and rheumatoid arthritis: Silymarin potentiates the anti-inflammatory effects of celecoxib by reducing the TNF-α and ROS in rats with osteoarthritis.29 Silibinin decreases the serum TNF-α levels and increases IL-10 compared to placebo in patients with active rheumatoid arthritis treated with low-dose MTX.30 Schümann et al31 reported that SLB has hepatoprotective effect by inhibiting the intrahepatic expression of TNF and increasing the synthesis of IL-10 in rats with T cell-dependent liver injury.