To achieve intelligent responsiveness, PEG‐PTD polymers were conjugated with a second PEG through a neutrophil elastase (NE)‐cleavable peptide, NH2‐RLQLKL‐C‐SH.[32] The resulting PEG‐flanked polymers can self‐assemble into micellular NPs that are responsive to NE, a protease highly enriched in the GBM tumor microenvironment (Figure S1, Supporting Information), by shrinking in size. The gene discussed is ELANE; the disease is glioblastoma.