CD4 and neoplasm: In HCC, TILs include innate immune cells and adaptive immune cells, the former contains tumor-associated macrophages (TAMs), tumor-associated neutrophils (TANs), NK cells, and DC cells, while the latter is composed of T lymphocytes, CD4 + /CD8 + T cells, regulatory T cells (Tregs), and myeloid-derived suppressor cells (MDSCs) [71].