MMP2 and neoplasm: In addition, some ECM components secreted by CAFs, such as periostin, tenascin-C, were involved in tumor migration and invasion [136, 137], and a variety of matrix metalloproteases (MMPs), including MMP1, MMP2, and MMP9, could also be produced by CAFs, which influenced tumor development via mediating ECM remodeling [138–140].