Recently, a study used Lrat-Cre-driven lox-stop-lox-TdTomato (TdTom) system to label HSCs in two ICC murine models, they found that in the context of ICC, 85%–95% of Col1a1-GFP + CAFs and 85%–93% of α-SMA + CAFs came from HSCs. This evidence concerns the gene COL1A1 and intrahepatic cholangiocarcinoma.