As shown, at 9 months of age, cytokine levels, including IL-6, IFNβ and Ccl5, were significantly higher in non-treated AD mice than those in WT mice, demonstrating that neurotoxic Tau could also induce cytokine storm in AD mice (Fig. 5E, Additional file 7: Fig. S6C–E). Here, MAPT is linked to Alzheimer disease.