It is well-established that aggregated pTau results in microtubule destabilization, defective axonal transport, and neuronal damage; however, the precise mechanism through which this devastating pathology ultimately affects neuronal death remains unclear. Studies in human AD brains have shown that necroptosis activation is triggered by the RIPK1/RIPK3/MLKL complex and contributes to chronic neuronal death in AD. The gene discussed is RIPK3; the disease is Alzheimer disease.