Furthermore, utilizing high throughput omic approaches, we have identified significant alterations to key players in P53 signaling, P13K-AKT signaling, cell cycle, apoptosis, WNT, MAPK, and various pathways in cancer as well as steroid hormone biosynthesis signaling pathways under mPR-specific PRG actions or disrupted CSC conditions. The gene discussed is TP53; the disease is cancer.