To elucidate mechanisms of the CSC’s involvement in breast cancer tumorigenesis and based on our initial TCGA expression profiling (Fig. 1), we screened candidate tumor cell lines and identified Luminal-A breast cancer cell line, T47D, as having higher endogenous expression, and a richer composition, of CCM2 isoforms (Additional file 1: Fig. S2), which were recently defined [10]. Here, CCM2 is linked to neoplasm.