Additionally, we observed that while no induced RNA expression of AR was observed, inducible RNA expression of GR was observed under mPR-specific PRG actions in both Luminal-A breast cancer cells (Additional file 1: Fig. S5), suggesting GR induction may result from its strong binding affinity to MIF, unrelated to their differential tumorigenic performances (Fig. 6A, B). Here, MIF is linked to breast cancer.