AR and neoplasm: As shown in Figure 4A–F, neither the bare Au nanoparticles nor the Au‐Peptide Control had a therapeutic effect on tumor growth, the Au‐AR DBD PROTAC showed great efficiency in both the C4‐2 and CWR22Rv1 xenograft models, and enzalutamide inhibited tumor growth in the C4‐2 but not the CWR22Rv1 xenograft model.