MAPK8 and hepatocellular carcinoma: Interestingly, with the exception of PDXO8, we observed a significant positive correlation (r = 0.7187, P < 0.01) between JNK pathway score and drug combination IC50 values (Fig. 6J), indicating that HCC tumor cells with lower basal levels of JNK signaling were more sensitive to Ixa + Dina treatment.