JUN and neoplasm: Furthermore, immunohistochemical analysis of PDX1 and PDX11 tumor tissues also revealed a significant reduction in Ki67 protein levels (Fig. 8A and C; P < 0.01) and concurrent increase in c-Jun levels (Fig. 8A and D; P < 0.01) after Ixa + Dina combination treatment, as compared to vehicle, single-drug, and sorafenib treated tumors.