Pearson analysis showed a negative correlation between miR-216b and IGF2BP2 in ESCC samples (r = -0.4596, p = 0.0005, Fig. 5C), and LIPH-4 and IGF2BP2 were positively correlated (r = 0.7552, p < 0.0001) (Fig. 5D). This evidence concerns the gene IGF2BP2 and esophageal squamous cell carcinoma.