Ovarian cancer patients, however, are typically tested for Lynch syndrome genes only if they have prior personal or family history that meets Lynch syndrome GT criteria, their tumors have endometrioid/clear cell histology, or are demonstrated to harbor MSI and/or mismatch repair (MMR) protein deficiency, although MSI and MMR profiling are not routinely performed for ovarian cancer patients at all institutions. The gene discussed is MRC1; the disease is ovarian cancer.