TP53 and breast carcinoma: High-penetrance genes that implicate breast cancer risk and are often targeted in the presence of additional features in the patient’s personal and/or family history [29, 50–52] and had positive results in our cohort include NF1 with 0.2% (n = 5), TP53 with 0.2% (n = 5), and CDH1 with 0.09% (n = 2) yield.