MSH2 and Lynch syndrome: The highest rate of positive results was in APC, with the low-penetrance p.Ile1307Lys variant identified in 1.8% (n = 38) and other APC variants in 0.2% (n = 5), followed by monoallelic MUTYH variants in 1.7% (n = 36), and Lynch syndrome-associated variants in MSH2, MLH1, MSH6, and PMS2 [30] identified in 1.2% (n = 25), 1.1% (n = 23), 0.8% (n = 16), and 0.6% (n = 13) of the patients, respectively.