POLD1 and colorectal cancer: P/LP variants in other genes that have been associated with colorectal cancer [30, 57], CHEK2, NTHL1 (monoallelic variants), MSH3 (monoallelic variants), POLD1, BMPR1A, and SMAD4, were identified in 1.6% (n = 34), 0.3% (n = 7), 0.1% (n = 2), 0.05% (n = 1), 0.05% (n = 1), and 0.05% (n = 1) of the patients, respectively.