Malaria RDTs can detect the following three reliable target antigens: histidine-rich protein-2 (HRP2), parasite-specific lactate dehydrogenase (LDH) (species specific and pan specific), and Plasmodium aldolase, of which HRP2 antigen is the preferred and most commonly used for the detection of P. falciparum, due to its high abundance in the blood, high heat stability and species-specificity [6]. In sub-Saharan Africa, 99% of malaria is caused by P. This evidence concerns the gene HDGFL2 and malaria.