The ASPSCR1-TFE3 fusion gene leads to aberrant transcription of hypoxia-inducible factor 1α (HIF-1α), which upregulates proangiogenic factors, including vascular endothelial growth factor (VEGF) and hepatocyte growth factor receptor (MET/HGFR), and induces immunosuppression in the tumor microenvironment [20, 21]. This evidence concerns the gene MET and neoplasm.